We at Krish Biotech Research has more than 12 years of experience in GLP complaint toxicity studies (safety assessment studies). We can perform the studies in compliance with global regulatory guidelines such as ICH, FDA, EMA, EU, OECD, OPPTS, JMAFF, CIB etc. We can also support you with tailor made studies as per specific requirement from various regulatory bodies.

Below are the list of toxicity studies performed at Krish Biotech Research:

6 Pack Acute Studies

• Acute Oral Toxicity
• Acute Dermal Toxicity
• Acute Inhalation Toxicity
• Skin Irritation
• Eye Irritation
• Skin Sensitization/ LLNA

Repeat Dose Studies

• Sub-acute, Sub-chronic & Chronic
• Repeated Dose Inhalation
• Carcinogenicity
• Combined Chronic / Carcinogenicity
• CNS safety
• Acute / Delayed Neurotoxicity

Developmental & Reproduction

• Pre-Natal Developmental
• Two Generation Reproduction
• Reproduction Developmental Screen
• Combined Repeated Dose Toxicity Study with Reproduction/ Developmental Toxicity Screening Test
• Male Fertility
• Extended One-Generation Reproductive Toxicity Study

Genetic Toxicology

In vivo & In Vitro Assays

• Bacterial Reverse Mutation Test (AMES)
• In vivo Mammalian Erythrocyte Micronucleus Test
• In vitro Mammalian Chromosome Aberration Test
• In vivo Chromosomal Aberration Assay in Bone Marrow Cells
• In vitro Mammalian Cell Gene Mutation test using the Hprt and Xprt locus
• In vitro Mammalian Cell Micronucleus Test
• In vitro Mouse Lymphoma Assay

Ecotoxicology

Terrestrial and Aquatic

• Growth Inhibition Test Algae and Lemna
• Acute Immobilization – Daphnia
• Fish Toxicity Test (Carp, Trout, Zebra etc.)
• Honeybees Toxicity (Oral and Contact)
• Earthworm Acute & Reproduction Toxicity
• Avian Oral & Dietary Toxicity Test
• Silk Worm Toxicity test
• Toxicity to Soil Microorganism and activated sludge
• Nitrogen Transformation
• Carbon Transformation